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Protease Inhibitors and St. John’s Wort: Why Mixing Them Causes Treatment Failure

Protease Inhibitors and St. John’s Wort: Why Mixing Them Causes Treatment Failure

by Gareth Ringwood / March 30, 2026/ 11

Mixing St. John's Wort with HIV protease inhibitors drastically lowers drug levels, risking viral resistance. Learn the biological mechanism, management steps, and safe alternatives.

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